Acetyl Cysteine

Best

Antioxidant

Acetyl Cysteine description

Acetyl cysteine, known also as aceytlcysteine, n-acetylcysteine and NAC, is an ingredient used for years in clinical settings to treat acetaminophen overdose. It is a derivative of the amino acid l-cysteine and is a precursor of the body’s master antioxidant, glutathione. In recent years, scientists have discovered new properties and uses for acetyl cysteine, one of which is its value as an anti-aging ingredient in skin care. As a precursor to glutathione, it also has antioxidant properties and with it, free-radical scavenging abilities that fight premature signs of aging. Acetyl cysteine also showed skin-calming effects and in some studies improved skin hydration via decrease of trans-epidermal water loss. The independent Cosmetic Ingredient Review Expert Panel has ruled acetyl cysteine safe in its current usage and practice in cosmetics. Use levels of acetyl cysteine in cosmetics range from 0.0005-0.1%.

Acetyl Cysteine references

  • Journal of Clinical and Aesthetic Dermatology, May 2019, pages 20-26
  • Indian Journal of Dermatology, Venereology and Nephrology, November-December 2018, pages 652-659
  • International Journal of Toxicology, May-June 2017, pages 17S-56S
  • Journal of Dermatological Science, May 2017, pages 4-19
  • Cell Journal, December 2016, pages 11-17
  • Annals of Dermatology, July 2015, pages 450-451
  • Journal of Investigative Dermatology, May 2003, pages 835-841

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Ingredient ratings

Best

Proven and supported by independent studies. Outstanding active ingredient for most skin types or concerns.

Good

Necessary to improve a formula's texture, stability, or penetration.

Average

Generally non-irritating but may have aesthetic, stability, or other issues that limit its usefulness.

Bad

There is a likelihood of irritation. Risk increases when combined with other problematic ingredients.

Worst

May cause irritation, inflammation, dryness, etc. May offer benefit in some capability but overall, proven to do more harm than good.

unknown

We couldn't find this in our ingredient dictionary. We log all missing ingredients and make continuous updates.

Not rated

We have not yet rated this ingredient because we have not had a chance to review the research on it.