25% Vitamin C + Glutathione Clinical Serum Full Size
25% Vitamin C + Glutathione Clinical Serum Full Size
25% Vitamin C + Glutathione Clinical Serum Full Size

25% Vitamin C + Glutathione Clinical Serum

€ 69,00 € 58,65
15% off
  • This advanced serum features highly stable 25% vitamin C and visibly improves uneven tone, radiance, elasticity & firmness without irritation.

  • Is this suitable for my skin? Take the quiz
  • Skin Type: All skin types
  • Skin Type: + All skin types
  • Concern: Anti-Aging, Brown spots, Dull skin
  • Ingredients: Vitamin C, Glutathione, Ergothioneine View all
  • Routine: Treatment
Skin Type:
+ All skin types
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How does it work?

  • Targets sun damage & improves uneven tone and discolouration

  • Boosts radiance & visibly brightens

  • Visibly firms & improves elasticity

The future of vitamin C.

This lightweight serum is clinically proven to improve uneven skin tone & discolouration while boosting radiance and brightening dullness. The targeted formula visibly firms and improves elasticity so you get advanced results – without irritation.


94% had visibly improved discolouration
91% had brighter-looking skin​
0% reported irritation*​

*Based on an independent clinical study with 32 subjects after 8 weeks


Find out if this formula works for you.

Because skincare works best when it suits your skin type.

What is your skin type?


Wash your face with a gentle cleanser and wait 15-30 minutes. Select what you see and how you feel.

What skin concern would you like to address?

WE KNOW SKIN. (Please select one option).

What's inside?

Key ingredients

Vitamin C

Vitamin C
One of the most well-researched vitamins for skin, shown to improve the look of multiple signs of ageing, brighten uneven skin tone, as well as provide skin-restoring and soothing benefits.


The body's master antioxidant that prevents oxidative damage, inflammation (which can accelerate ageing) and strengthens the skin’s barrier.



Potent, mushroom-derived antioxidant that boosts the skin’s environmental defences and ability to prevent premature signs of ageing.

The full ingredient list:

Aqua (Solvent), Tetrahexyldecyl Ascorbate (Antioxidant), Dimethicone (Skin conditioning agent), Glycerin (Humectant), C9-12 Alkane (Emollient), Ascorbyl Glucoside (Skin brightening agent, Silica (Opacifying agent), Pyrus Malus (Apple) Fruit Extract (Skin conditioning agent), Hydrogenated Lecithin (Skin conditioning agent), Polyglyceryl-6 polyricinoleate (Emollient), Mannitol (Skin conditioning agent), Sodium Hydroxide (Solvent), Acrylates/C10-30 Alkyl Acrylate Crosspolymer (Viscosity controlling agent), Xanthan Gum (Emulsion stabilizer), Glutathione (Antioxidant), Ergothioneine (Antioxidant), Oryza Sativa (Rice) Bran Extract (Skin conditioning agent), Hydroethyl Acrylate/Sodium Acryloylmethyl Taurate Copolymer (Dispersing agent), Cetyl Alcohol (Emulsion stabilizer), Caprylyl Glycol (Skin conditioning agent), Lysine Carboxymethyl Cysteinate (Skin conditioning agent), Coco-Caprylate/Caprate (Skin conditioning agent), Tocopherol (Skin conditioning agent), Sodium Citrate (pH adjuster), Sodium Phytate (Chelating agent), Hexylene Glycol (Emulsifier), Ethylhexylglycerin (Skin conditioning agent), Helianthus Annuus (Sunflower) Extract (Emollient), Urea (Humectant), Caprylic/Capric Triglyceride (Skin conditioning agent), Sodium PCA (Skin conditioning agent), Rosmarinus Officinalis (Rosemary) Leaf Extract (Skin conditioning agent), Polysorbate 60 (Surfactant), Sorbitan Isostearate (Surfactant), Trehalose (Humectant), Ascorbic Acid (Skin conditioning agent), Glucose (Solvent), Vanilla Planifolia Fruit Extract (Skin conditioning agent), Polyquaternium-51 (Humectant), Triacetin (Solvent), Sodium Hyaluronate (Skin conditioning agent), Phenoxyethanol (Preservative). [IL360v3]

How to use

Step 4 Treatments 25% Vitamin C + Glutathione Clinical Serum

How to use a serum

Apply onto face and neck. For optimal results, use AM and PM. For daytime, always follow with a broad spectrum sunscreen rated SPF 30 or greater.

Here's a step-by-step of your morning & evening skincare application.
Step 1: Cleanser
Wet your face and apply a small amount with gentle, circular motions. Rinse well. To remove heavy makeup, repeat or use with a clean, wet washcloth.
Step 2: Toner
With your fingertips or a cotton pad, gently apply over the face and neck. Do not rinse.
Step 3 Exfoliants
Gently apply with your fingertips or a cotton pad over the face and neck, including the eye area (avoid lash line and eyelids). Do not rinse. Start slowly: Apply every other day and note your skin's response. Then use up to twice daily.
Step 4 Treatments
Dispense a pearl-sized amount to your hand and apply once or twice daily to the face, neck and eye area.
Step 5 Moisturisers
Use a day moisturiser as the last step in your morning skincare routine and apply liberally at least 15 minutes before stepping into sun exposure. As always, it's best to reapply every two hours once the skin has been exposed to direct sunlight. For a night moisturiser, apply a small amount once or twice daily to the face and neck.
25% Vitamin C + Glutathione Clinical Serum



Most asked

How is it different to other vitamin C serums?

25% Vitamin C + Glutathione Clinical Serum is formulated with a highly stable blend of oil-and-water soluble vitamin C for optimal effectiveness. Glutathione + GAP technology (glutathione amino acid precursors) work to minimise irritation while amping up antioxidant protection and ingredient stability. This advanced formula helps sustain a natural level of glutathione & vitamin C within the skin’s uppermost layers for extended results, while also reducing oxidative stress that triggers discolouration.

Who should use 25% Vitamin C + Glutathione Clinical Serum?

The 25% Vitamin C + Glutathione Clinical Serum is for all skin types, skin tones and ages. It’s best for those showing numerous, more stubborn signs of sun damage, including discolouration, a dull complexion and moderate loss of firmness.

What is the difference between 25% Vitamin C + Glutathione Clinical Serum and C15 Super Booster?

The 25% Vitamin C + Glutathione Clinical Serum contains two vitamin C esters: 23% tetrahexyldecyl ascorbateand 2% ascorbyl glucoside, and is best suited for those with advanced concerns of discolouration, uneven skin tone and lack of firmness. The C15 Super Booster contains 15% pure ascorbic acid (vitamin C) and is a great option for everyone who wants a daily dose of vitamin C to help fortify skin and improve minor skin discolouration or dullness. It can be used alone or mixed into your favourite serum or night (non-SPF) moisturiser.
Each product can be used on its own or in combination with one another (e.g., C15 during the day and 25% Vitamin C at night). Whether to use one or both will depend on your primary concerns and tolerance for these ingredients. We suggest experimenting to see what works best for your skin. As with all bioactive ingredients, start slowly and increase use as desired/needed.
Note: You may notice ascorbic acid listed at the bottom of the ingredient list for this product. The ascorbic acid is present in this formula in incidental amounts. As such, it does not have a brightening or antioxidant benefit to the skin. Instead, it's part of the ascorbyl glucoside blend, used to help keep it stable and in the ideal pH range prior to being added to a cosmetic formula.

What is the difference between 25% Vitamin C + Glutathione Clinical Serum and the C25 Super Booster?

The 25% Vitamin C + Glutathione Clinical Serum is a comprehensive formula made for all-over facial use. With 23% tetrahexyldecyl ascorbate and 2% ascorbyl glucoside, it’s the most potent vitamin C product we offer and a great option for targeting stubborn concerns such as discolouration, uneven skin tone, fine lines and wrinkles.
The formula is water-based and contains several supporting ingredients, including potent antioxidants glutathione and ergothioneine. It also includes GAP technology, an amino acid blend proven to boost skin’s glutathione levels for enhanced activity of vitamin C and improved pollution defence (which helps further minimise the intensity of dark circles). While the C25 Super Booster is a great product, it is meant for spot application and its simpler formula relies on 25% l-ascorbic acid to help fade discolouration.

What is the difference between 25% Vitamin C + Glutathione Clinical Serum and CLINICAL Discolouration Repair Serum?

The 25% Vitamin C + Glutathione Clinical Serum contains 23% tetrahexyldecyl ascorbate and 2% ascorbyl glucoside, plus glutathione, GAP Technology and ergothioneine. This serum is great for targeting uneven tone, discolouration and loss of firmness. The CLINICAL Discolouration Repair Serum contains 3% tranexamic acid, 5% niacinamide and 0.5% bakuchiol which is ideal for targeting discolouration and is even suitable for those with melasma-prone skin. It’s also soothing, which can reduce signs of redness. It’s perfectly fine - and in some cases may be advisable - to layer both products as part of your strategy to fade various types of hyperpigmentation, including post-breakout marks.

Where should I store 25% Vitamin C + Glutathione Clinical Serum?

While there is research that supports it’s okay to keep water-based ascorbic acid (pure vitamin C) in the refrigerator to help prolong stability and delay in colour change, it’s important to note that this only applies to ascorbic acid in water. This does not apply to other ingredients or forms of vitamin C or when ascorbic acid is present without water. The only vitamin C product in the Paula’s Choice collection that we say is okay to store in the refrigerator is our C15 Super Booster, but even then, such storage is optional; room temperature is ideal. For other products, long-term exposure to cold temperatures can shorten the product’s lifespan, negatively impact stability and affect performance.
The 25% Vitamin C + Glutathione Clinical Serum was deemed best stored at room temperature which is typically 20-22 C. Refrigerating it to preserve the incidental amount of ascorbic acid would have a net negative effect on many of the other ingredients not meant for long-term cold storage. Note: The PAO (period after opening) for the 25% Vitamin C + Glutathione Clinical Serum is 12 months. For more information about refrigerating skincare products and our products' shelf life, please contact our dedicated customer service team.

Can you mix 25% Vitamin C + Glutathione Clinical Serum with C15 Super Booster or layer under C5 Super Boost Moisturiser?

Yes. In fact, you will see enhanced results and not have to worry about irritation since the forms of vitamin C in the 25% Vitamin C + Glutathione Clinical Serum do not have the same low pH requirements as pure ascorbic acid. You will get better free radical protection, better environmental defence and enhanced improvements in discolouration, wrinkles and loss of firmness. We recommend starting slow with multiple bioactive products to see how your skin responds and increase use over time as needed/desired.

Can you mix 25% Vitamin C + Glutathione Clinical Serum with other bioactive products?

Yes, research has shown that vitamin C works well and can be used with other beneficial ingredients including niacinamide, retinol, peptides (except copper peptides, which Paula’s Choice does not use) and exfoliating acids. If you are currently using a prescription skincare product, we recommend consulting with your doctor for guidance on incorporating this serum into your routine.
Here’s a few of our favourite combos: Vitamin C + Retinol: Retinol (in the form of retinyl palmitate) and vitamin C (ascorbic acid) are naturally present in skin, where they work to keep it healthy. Vitamin C and retinol can coexist and maintain their benefits in a single formula, or they may be formulated separately and layered.
Vitamin C + Peptides: Vitamin C plays well with almost all peptides, working to protect skin and helping it to repair damage. The only exception: copper peptides. These can oxidise vitamin C, making it less effective to skin. When using vitamin C and copper peptides in your routine, we recommend using one in the morning and the other at night to ensure maximum effectiveness.
Vitamin C + Niacinamide: Together, vitamin C and niacinamide form a powerhouse combo that addresses uneven tone, wrinkles, loss of firmness and dullness. All skin types will see a complexion that becomes more radiant, smoother, more even and healthier looking when pairing the two ingredients.
Vitamin C + AHA/BHA: The exfoliating action of AHA or BHA helps shed the build-up of skin cells that in turn allow vitamin C to penetrate past the skin’s surface. Using AHA/BHA prior to applying vitamin C helps target discolouration and brighten more effectively.

Is 25% Vitamin C + Glutathione Clinical Serum good for breakout-prone skin?

Yes, when used with our CLEAR collection, the soothing benefits of vitamin C and key antioxidants in this serum can help to reduce some of the inflammation that drives acne. These ingredients can also help to fade post-breakout marks of any colour.

Is 25% Vitamin C + Glutathione Clinical Serum good for rosacea or sensitive skin?

This may vary from person to person due to the amount of vitamin C in the formula which may prove too potent. We suggest patch testing this product on a small area to see how your skin responds. Vitamin C's soothing action on the skin can be helpful for rosacea, as can the anti-redness benefits of glutathione and ergothioneine. Besides, unlike water-based ascorbic acid formulas, this serum has a higher pH of 5.5-6.0 , which decrease the risk of irritation. If you've experienced sensitisation to higher amounts of vitamin C, we recommend you consider our C5 Super Booster Moisturiser , which contains 5% vitamin C.

Is it safe to use 25% Vitamin C + Glutathione Clinical Serum during pregnancy or while breastfeeding?

The ingredients in the 25% Vitamin C + Glutathione Clinical Serum are generally considered safe to use during pregnancy or while breastfeeding. However, if you’re uncertain about starting a new anti-ageing product or a combination of ingredients, check with your doctor and follow their advice.

How do you apply 25% Vitamin C + Glutathione Clinical Serum?

Smooth a pea-sized amount over face and neck. For optimal results, use AM and PM. For daytime, follow with a broad-spectrum sunscreen rated SPF 30 or greater. We recommend layering the products in your routine from thinnest to thickest texture.

How often should you apply 25% Vitamin C + Glutathione Clinical Serum?

The 25% Vitamin C + Glutathione Clinical Serum can be applied up to twice per day, in your AM and PM routine. How often to apply will vary based on your concerns and tolerance. If new to using vitamin C or higher concentrations of the ingredient, start slow (2-3 times per week), see how your skin responds, and then work up to increasing to daily use.

Why is the new 25% vitamin C serum named 25% Vitamin C + Glutathione Clinical Serum vs C25?

The name 25% Vitamin C + Glutathione Clinical Serum was chosen to better distinguish that this all-over facial serum is not a direct replacement for the C25 Super Booster but instead a completely new innovation for all skin types.

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Product out of stock

25% Vitamin C + Glutathione Clinical Serum Full Size

25% Vitamin C + Glutathione Clinical Serum

Full size
€ 69,00
15% off
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