Malassezin

Malassezin is an ingredient derived from Malassezia furfur; a type of yeast found naturally on the surface of human skin. While certain strains of this yeast have been associated with skin conditions including folliculitis, “fungal acne” and dandruff, its derivative yields a much different result. Recent studies indicate that in addition to providing antioxidant benefits, malassezin interrupts factors that lead to skin discolorations – but in a way that’s different from most traditional methods. Ingredients such as hydroquinone and tranexamic acid are so effective because they interfere with tyrosinase, an enzyme whose overproduction can trigger excess, uneven melanin production, leading to dark spots and patches. Research so far indicates that malassezin fights skin discolorations by inducing what is known as melanocyte apoptosis – essentially, the programmed death of melanocytes, the cells responsible for producing melanin in skin. While this might sound somewhat bad, this process helps ensure melanin production doesn’t become overactive, potentially helping restore skin’s natural, uniform color. Clinical studies have found malasseizin in amounts as low as 0.1% effective in minimizing the appearance of discolorations; however, we should note there is no breadth of research yet comparing its effectiveness against other treatments for hyperpigmentation. We also need to learn more about the extent of cell death it causes, and how skin’s antioxidant defense system may control this process. Novel approaches to fading hyperpigmentation for brighter skin are exciting, but time will tell how this particular approach stacks up against the tried-and-true options.

Related ingredients: Yeast Yeast Extract