Urolithin A

Excellente

Antioxidante

Urolithin A at a glance

  • Naturally produced inside the gut
  • Byproduct of ellagic acid digestion
  • Has antioxidant properties
  • Helps prevent cell senescence

Urolithin A description

Urolithin A is an antioxidant-rich natural compound produced when microbes inside the gut break down foods rich in ellagic acid, such as pomegranates, nuts and many types of berries. Ellagic acid is a polyphenol antioxidant. Its metabolite, urolithin A, also has antioxidant benefits, backed by studies showing it has potent free radical-scavenging abilities. Even more promising is research demonstrating that it can enhance skin longevity by preventing cell senescence. Cell senescence is one of the key biomarkers of aging. It’s a process where cells stop dividing and start sending inflammatory messages to nearby, healthy cells. Premature cell senescence increases skin’s biological age, resulting in the well-known signs of aging including wrinkles, discolorations and skin losing its ability to repair itself. Studies demonstrate urolithin A can mitigate the effects of senescence, including that caused by UVA radiation, which is a leading cause of skin aging and a contributor to every type of skin cancer. Additional research indicates that urolithin A may work by increasing removal of damaged mitochondria (mitophagy) and improving mitochondrial health. This leads to re-energizing the cells to reducing the breakdown of collagen and prolonging skin health. More research is needed, but urolithin A shows a lot of potential in becoming an anti-aging ingredient to watch. Urolithin-A may be plant-derived or synthetic. The research-supported use level of this ingredient in cosmetics is 1%.

Urolithin A references

  • Frontiers in Medicine, September 2024, pages 1-14
  • Journal of Photochemistry and Photobiology B: Biology, July 2022, page 112,462
  • Frontiers in Pharmacology, March 2022, pages 1-10
  • Antioxidants, February 2020, pages 1-16
  • Rejuvenation Research, June 2019, pages 191-200
  • Food and Chemical Toxicology, October 2017, pages 289-297

Peer-reviewed, substantiated scientific research is used to assess ingredients in this dictionary. Regulations regarding constraints, permitted concentration levels and availability vary by country and region.

Calificaciones de ingredientes

Excelente

Ingrediente sobresaliente con beneficios reales para la piel. Su eficacia está demostrada y respaldada por estudios independientes.

Bueno

Aunque no son tan beneficiosos como los de la categoría excelente, suelen ser necesarios para mejorar la textura, la estabilidad o la absorción de una fórmula.

Aceptable

Puede presentar ciertas limitaciones en cuanto a su apariencia, estabilidad o eficacia. A veces, son ingredientes básicos o que no cuentan con suficiente respaldo científico.

Poco recomendable

Aunque puede ofrecer algunos beneficios se recomienda evitarlo por su probabilidad de causar irritación, especialmente si se combina con otros ingredientes problemáticos.

Desaconsejable

Ha demostrado provocar efectos adversos como irritación, inflamación o sequedad, especialmente si se utiliza en altas concentraciones o junto con otros ingredientes irritantes.

Desconocido

No hemos encontrado este ingrediente en nuestro diccionario. Registramos todos los ingredientes desconocidos y actualizamos la información de forma continua.

Sin calificar

Ingrediente registrado, pero con la información científica disponible pendiente de revisar.